Microreviews
Protein quality control meets transcriptome remodeling under stress
Veena Mathew1 and Peter C. Stirling1
Protein quality control (PQC) is an essential part of cellular homeostasis and encompasses the balance of non-native protein folding and degradation. Under stress, triage of non-native or disassembled proteins to
Exploding the necroptotic bubble
Liat Edry-Botzer1 and Motti Gerlic1
Several new types of regulated cell death have emerged from analysis of necrotic forms of cell death; one example is necroptosis, a RIPK3-MLKL-dependent and caspase-independent form of cell death. Although
Fumarase mediates transcriptional response to nutrient stress
Qin Zhao1 and Yuhui Jiang1
To date, emerging evidence demonstrate that metabolites participate in a wide variety of cellular activities besides their direct role in metabolism. Previous studies have reported that metabolic activity of FH
Senescence explains age- and obesity-related liver steatosis
Mikolaj Ogrodnik1 and Diana Jurk1,*
In a study recently published in the journal Nature Communications we have researched the role of cellular senescence during liver ageing, in obesity and NAFLD. We observed that hepatocyte fat