Microreviews
Therapeutic potential of DNA methyltransferase inhibitors with immune checkpoint inhibitor therapy in breast cancer
Na Luo1, Ayaka Sugiura2 and Justin M. Balko1,3,4,5
Tumor infiltrating lymphocytes (TILs) are a positive prognostic biomarker in breast cancer, particularly in hormone receptor-negative disease. High TILs associate with an improved survival rate in breast cancer patients, and
A new way to regulate inflammation: selective autophagic degradation of IKKγ mediated by ANGPTL8
Yu Zhang1, Ling Zheng2 and Kun Huang1
Activation of transcription factor nuclear factor-κB (NF-κB) is one of the central events in inflammation and immunity. In resting cells, the activity of NF-κB is inhibited by its binding partner,
Salmonella Typhimurium infection: Type I Interferons integrate cellular networks to disintegrate macrophages
Nirmal Robinson1,2
Salmonella enterica serovar Typhimurium (S. Typhimurium) are facultative intracellular bacteria that effectively evade innate immune defense mechanisms using a plethora of pathogenic principles encoded in their pathogenicity islands namely Salmonella
miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia
Pragnya Das1, Mansoor Ali Syed1,2, Dilip Shah1, Vineet Bhandari1,3,*
BPD has been getting more attention as neonatologists from across the world are getting better in saving the lives of premature neonates. This has mobilized intense research to fill the
Therapeutic potential of HDAC6 in amyotrophic lateral sclerosis
Wenting Guo1,2 and Ludo Van Den Bosch1,2
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the selective death of motor neurons in the motor cortex, brainstem and spinal cord. This leads to progressive muscle weakness,
Targeting Nfix to fix muscular dystrophies
Giuliana Rossi1, Valentina Taglietti2 and Graziella Messina2
A shared knowledge in the field is that to be really successful, any therapeutic strategy has to rely on good muscle quality. In fact, there is no available approach able
New insight into the role of autophagy in tumorigenesis
Yongjun Tian1, Linya Wang2 and Jing-hsiung James Ou2
TP53, commonly known as p53, is an important tumor suppressor. Its increased expression was observed not only in the liver tumors of our Atg5-knockout mice but also in the lung