Volume 10 (2026)
Cover: Public domain image of an artist's impression of a neuron network. Image by Jean Beaufort (Link). Image modified by Cell Stress. The cover is published under the CC BY 4.0 license
MicroRNA as key players in skin regeneration and anti-aging pathways
Hanieh Azizi1, Reza Moghadasali2, Amir Mohammad Amirkhani3, Ehsan Taghiabadi3 and Mohammad Ali Nilforoushzadeh3,4
For full text please see pdf.
Stress management by benzodiazepines in septic shock and critical illness: mechanistic and clinical evidence supporting alternative sedative strategies
Flavia Lambertucci1, David Skurnik2,3, Damien Roux4,5, Laurence Arbibe6, Lucillia Bezu1,7,8, Isabelle Martins1 and Guido Kroemer1,7,9
For full text please see pdf.
Triptolide inhibits ovarian cancer growth and metastasis via reprogramming of tumor-associated macrophages
Ziqi Chen1,2,a, Jie Zhang3,a, Jianting Lao4, Chaoqin Yu5 and Hong Yang1,4
For full text please see pdf.
The IRE1α-XBP1s-NFκB axis controls cell survival and epithelial differentiation under osmotic stress through arachidonic acid metabolism activation
Leandro Gastón Parra1,5, Cecilia Irene Casali1,5, Dylan Ezequiel Sendyk1,5, Ailén Florencia Salafia1, Sabrina Andrea Flor3,4,6, Silvia Edith Lucangioli2,4,6 and María del Carmen Fernández Tome1,5,*
Arachidonic acid (AA) metabolism plays a critical role in renal cell osmoadaptation. We recently demonstrated that hypertonicity induces the expression and activation of cytosolic phospholipase A2 (cPLA2). On one hand, AA released by cPLA2 enhances triacylglyceride (TG) synthesis and accumulation. On the other hand, AA is converted into prostaglandins (PG) through cyclooxygenase 2 (COX2) activity. Both processes are required for renal cell survival under osmotic stress. However, the mechanisms by which hypertonicity induces cPLA2 expression remain poorly understood. Given that we previously shown that hypertonicity regulates TG synthesis through the IRE1α-XBP1s branch of the unfolded protein (...)
Multifaceted role of CNPY2 beyond ER stress: Disease implications and therapeutic potential
Shima Ebadollahibaruq1,2, Lingbin Meng2 and Feng Hong1,2,*
This review meticulously dissects CNPY2’s structural characteristics, expression patterns, and biological functions across various disorders, emphasizing its role on tumor initiation, microenvironmental stress, and chemoresistance, and evaluating its potential as a therapeutic target.
Antifungal peptides: from modes of action to synergistic and immunologic potential
Didac Carmona-Gutierrez1,2,#,*, Maria A. Bauer1,#, Katharina Kainz1¸ Martin N. Odabas1 and Frank Madeo1-3,*
Reversal of Cushing syndrome by antibody-mediated neutralization of ACBP/DBI
Zhe Shen1,2,3,a, Hui Pan1,2,4,a, Xiaolian Deng1,2,3, Oliver Kepp1,2, Isabelle Martins1,*, and Guido Kroemer1,2,5,*
For full text please see pdf.
MicroRNA as key players in skin regeneration and anti-aging pathways
Hanieh Azizi1, Reza Moghadasali2, Amir Mohammad Amirkhani3, Ehsan Taghiabadi3 and Mohammad Ali Nilforoushzadeh3,4
For full text please see pdf.
Stress management by benzodiazepines in septic shock and critical illness: mechanistic and clinical evidence supporting alternative sedative strategies
Flavia Lambertucci1, David Skurnik2,3, Damien Roux4,5, Laurence Arbibe6, Lucillia Bezu1,7,8, Isabelle Martins1 and Guido Kroemer1,7,9
For full text please see pdf.
Triptolide inhibits ovarian cancer growth and metastasis via reprogramming of tumor-associated macrophages
Ziqi Chen1,2,a, Jie Zhang3,a, Jianting Lao4, Chaoqin Yu5 and Hong Yang1,4
For full text please see pdf.
The IRE1α-XBP1s-NFκB axis controls cell survival and epithelial differentiation under osmotic stress through arachidonic acid metabolism activation
Leandro Gastón Parra1,5, Cecilia Irene Casali1,5, Dylan Ezequiel Sendyk1,5, Ailén Florencia Salafia1, Sabrina Andrea Flor3,4,6, Silvia Edith Lucangioli2,4,6 and María del Carmen Fernández Tome1,5,*
Arachidonic acid (AA) metabolism plays a critical role in renal cell osmoadaptation. We recently demonstrated that hypertonicity induces the expression and activation of cytosolic phospholipase A2 (cPLA2). On one hand, AA released by cPLA2 enhances triacylglyceride (TG) synthesis and accumulation. On the other hand, AA is converted into prostaglandins (PG) through cyclooxygenase 2 (COX2) activity. Both processes are required for renal cell survival under osmotic stress. However, the mechanisms by which hypertonicity induces cPLA2 expression remain poorly understood. Given that we previously shown that hypertonicity regulates TG synthesis through the IRE1α-XBP1s branch of the unfolded protein (...)
MicroRNA as key players in skin regeneration and anti-aging pathways
Hanieh Azizi1, Reza Moghadasali2, Amir Mohammad Amirkhani3, Ehsan Taghiabadi3 and Mohammad Ali Nilforoushzadeh3,4
For full text please see pdf.
Multifaceted role of CNPY2 beyond ER stress: Disease implications and therapeutic potential
Shima Ebadollahibaruq1,2, Lingbin Meng2 and Feng Hong1,2,*
This review meticulously dissects CNPY2’s structural characteristics, expression patterns, and biological functions across various disorders, emphasizing its role on tumor initiation, microenvironmental stress, and chemoresistance, and evaluating its potential as a therapeutic target.
Antifungal peptides: from modes of action to synergistic and immunologic potential
Didac Carmona-Gutierrez1,2,#,*, Maria A. Bauer1,#, Katharina Kainz1¸ Martin N. Odabas1 and Frank Madeo1-3,*
Stress management by benzodiazepines in septic shock and critical illness: mechanistic and clinical evidence supporting alternative sedative strategies
Flavia Lambertucci1, David Skurnik2,3, Damien Roux4,5, Laurence Arbibe6, Lucillia Bezu1,7,8, Isabelle Martins1 and Guido Kroemer1,7,9
For full text please see pdf.