Volume 9 (2025)
Burning fat with cysteine depletion
Brittney Adams1, Stanislaw Walkowiak1 and Mohammed K Hankir1
Adams and colleagues comment on two complementary articles by Varghese et al and Lee et al showing that cysteine depletion through combined dietary and genetic means in mice evokes a unique stress response in the liver to amplify these metabolic outcomes and offer a potentially new treatment option for obesity.
Quantifying replication stress in cancer without proliferation confounding
Philipp Jungk1 and Maik Kschischo1
The authors developed a refined gene expression signature (TRSS) that accurately measures replication stress independently of cell proliferation, addressing a major limitation of existing biomarkers that conflate stress with oncogene-driven growth. Applying this signature to patient samples, they discovered that replication stress is associated with activation of the non-homologous end-joining DNA repair pathway, suggesting cells may shift toward this repair mechanism under replication stress conditions.
Datopotamab deruxtecan induces hallmarks of immunogenic cell death
Sabrina Forveille1,2, Marion Leduc1,2, Allan Sauvat1,2, Guido Kroemer1,2,3 and Oliver Kepp1,2
For full text see pdf.
Oxidative stress induces cortical stiffening and cytoskeletal remodelling in pre-apoptotic cancer cells
Aiman Jalmukhambetova1, Aidana Baltabekova1, Aizhan Tolebay1, Nargiz Rakhimgerey1, Ferdinand Molnár1, Tri Thanh Pham1, Agata N. Burska2,3 and Dos D. Sarbassov1,3
For full text see pdf.
Role of mitochondrial dysfunction in ocular surface diseases
Xiaohan Chen1, Jiaxu Hong2,3,4,5 and Qihua Le1,3
For full text please see pdf.
Bax- Bcl-xL interaction dynamics during the progression of cell cycle and cell death using FLIM-FRET
Aman Munirpasha Halikar1,2, Aneesh Chandrasekharan1, Asha Lekshmi1, Aswathy Sivasailam1, Jain Tiffee P J1,2, Shivanshu Kumar Tiwari1,2, Aijaz Ahmad Rather1,2 and TR Santhoshkumar1
For full text please see pdf.
Burning fat with cysteine depletion
Brittney Adams1, Stanislaw Walkowiak1 and Mohammed K Hankir1
Adams and colleagues comment on two complementary articles by Varghese et al and Lee et al showing that cysteine depletion through combined dietary and genetic means in mice evokes a unique stress response in the liver to amplify these metabolic outcomes and offer a potentially new treatment option for obesity.
Quantifying replication stress in cancer without proliferation confounding
Philipp Jungk1 and Maik Kschischo1
The authors developed a refined gene expression signature (TRSS) that accurately measures replication stress independently of cell proliferation, addressing a major limitation of existing biomarkers that conflate stress with oncogene-driven growth. Applying this signature to patient samples, they discovered that replication stress is associated with activation of the non-homologous end-joining DNA repair pathway, suggesting cells may shift toward this repair mechanism under replication stress conditions.
Datopotamab deruxtecan induces hallmarks of immunogenic cell death
Sabrina Forveille1,2, Marion Leduc1,2, Allan Sauvat1,2, Guido Kroemer1,2,3 and Oliver Kepp1,2
For full text see pdf.
Oxidative stress induces cortical stiffening and cytoskeletal remodelling in pre-apoptotic cancer cells
Aiman Jalmukhambetova1, Aidana Baltabekova1, Aizhan Tolebay1, Nargiz Rakhimgerey1, Ferdinand Molnár1, Tri Thanh Pham1, Agata N. Burska2,3 and Dos D. Sarbassov1,3
For full text see pdf.
Role of mitochondrial dysfunction in ocular surface diseases
Xiaohan Chen1, Jiaxu Hong2,3,4,5 and Qihua Le1,3
For full text please see pdf.
Role of mitochondrial dysfunction in ocular surface diseases
Xiaohan Chen1, Jiaxu Hong2,3,4,5 and Qihua Le1,3
For full text please see pdf.
NFAT5: a stress-related transcription factor with multiple functions in health and disease
Alfredo Domínguez-López1,2, Fátima Sofía Magaña-Guerrero2, Beatriz Buentello-Volante2, Óscar Vivanco-Rojas1,2, Yonathan Garfias1,2
For full text please see the pdf.
Probiotics and mediterranean diet for breast cancer management and prevention?
Ehssan A. Sharif-Askari1, Khadija M. Atoui1, Ali K. Mteyrek2, Lama M. Fawaz3
The human gut microbiota, a diverse community of beneficial normal flora microorganisms, significantly influences physiological function and the immune response. Various microbiota strains have shown promise in supporting clinical treatment of chronic diseases, including cancer, by potentially providing antioxidative and anti-tumorigenic effects in both in vivo and in vitro studies. Breast cancer, which ranks amongst the top five cancer types common worldwide and particularly in Mediterranean countries, has been showing high incidence and prevalence. In breast cancer, microbiota composition, hormonal dynamics, and dietary choices are believed to play significant roles. Hence, the Mediterranean diet, known for its microbiota-friendly features, emerges as a potential protective factor against breast cancer development, highlighting the potential for personalized dietary strategies in cancer prevention. This comprehensive review highlights the emerging mechanisms by (...)
Burning fat with cysteine depletion
Brittney Adams1, Stanislaw Walkowiak1 and Mohammed K Hankir1
Adams and colleagues comment on two complementary articles by Varghese et al and Lee et al showing that cysteine depletion through combined dietary and genetic means in mice evokes a unique stress response in the liver to amplify these metabolic outcomes and offer a potentially new treatment option for obesity.