Exploding the necroptotic bubble
Authors:Liat Edry-Botzer1 and Motti Gerlic1
1 Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Keywords:
necroptosis, phosphatidylserine, cell death, extracellular vesicles, apoptosis, annexin V, phagocytosis, necroptotic bodies, MLKL, RIPK3, RIPK1.
Corresponding Author(s):
Conflict of interest statement:
The authors declare that they have no conflict of interest.
Please cite this article as:
Liat Edry-Botzer and Motti Gerlic (2017). Exploding the necroptotic bubble. Cell Stress1(2): 107-109. doi: 10.15698/cst2017.11.112
© 2017 Edry-Botzer and Gerlic. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
The apoptotic death of cells is accompanied by the exposure of “eat-me” signals that serve to prevent necrotic degradation of apoptotic cells, and thereby prevent inflammation, promote resolution of immune responses, and stimulate tissue repair. These “eat-me” signals include the exposure of phosphatidylserine (PS) on the outer plasma membrane during the early stages of apoptosis as well as on the surface of apoptotic bodies, plasma membrane vesicles that are shed during the later stages of cell death. In our recent publication (PLoS Biol. 15(6):e2002711), we describe similar ‘eat-me’ and ‘find-me’ signals present during necroptosis, challenging some of our common assumptions about regulated forms of lytic death.