Journal Impact Factor® 2025: 3.0
CiteScore® 2025: 4.8
The connection between inflammation and cancer has been well established; however, little is known about the underlying mechanisms in the context of keratin loss. Keratins belong to a large family … Read more
INTRODUCTION A variety of topological, structural and hybridization events occur during DNA replication and gene transcription. Unwinding of the DNA double helix provides access for polymerase to a template strand, … Read more
We found that under oxidative or proteotoxic stress conditions, the TRIM16 is required for biogenesis of protein aggregates from misfolded proteins. In our attempt to investigate the mechanism by which … Read more
INTRODUCTION The term autophagy (‘self-eating’ in Greek) refers to a group of evolutionarily conserved homeostatic mechanisms employed by eukaryotic cells to eliminate aged, unused, and damaged cytoplasmic components through lysosomal … Read more
The emerging RNA-based therapeutics are renowned for a wide array of druggable targets, which are difficult to achieve by conventional therapies, with high specificity and great versatility. RNA-based drugs function … Read more
INTRODUCTION Epigenetics is the regulation of gene expression independent of the gene sequence itself via the interactions between DNA and proteins called histones [cite]10.4161/epi.24042[/cite]. In the nucleus, DNA is highly … Read more
Intracellular Ca2+ signals critically control a plethora of cellular functions, of which many impact cellular death and/or survival, processes often dysregulated in cancer [cite]10.1038/nrc.2017.18[/cite]. In healthy cells, Ca2+ signaling is … Read more
VDAC ISOFORMS, STRUCTURE, AND CHANNEL ACTIVITY VDAC isoforms and cellular localization Three different VDAC isoforms, VDAC1, VDAC2 and VDAC3, sharing ~70% identity and structural and some functional properties [cite]10.1016/j.mam.2010.03.002[/cite][cite]10.1016/j.bbamem.2011.10.005[/cite], are … Read more
Everyday most organisms face the requirement to adapt their metabolic cues to the fluctuation of nutrient resources into the environment. When nutrients are abundant cells activate anabolic pathways, such as … Read more
Any disease that humanity encounters is preceded by a homeostatic disruption as a prelude to a consequent pathological state. Medical researchers and practitioners try to counteract this by designing and … Read more