Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics

Authors:

Chanh Tin Pham1, Xin Zhang1, Austin Lam1, Minh TN Le1
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Affiliations:

1 Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong.

Keywords: 

Cancer, RNA, therapeutics, extracellular vesicles, red blood cells.

Corresponding Author(s):

Minh TN Le, Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong mle.bms@cityu.edu.hk

Conflict of interest statement:

The authors declare no conflicts of interest.

Please cite this article as:

Chanh Tin Pham, Xin Zhang, Austin Lam, Minh TN Le (2018). Red blood cell extracellular vesicles as powerful carriers of RNA-based therapeutics. Cell Stress 2(9): 239-241. doi: 10.15698/cst2018.09.155

© 2018 Pham et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.

Abstract:

One of the major challenges of RNA-based therapeutics is the method for delivery of RNA molecules. In a recent article (Nat Commun 9(1):2359), we described a novel delivery platform for RNA-based drugs using red blood cell extracellular vesicles which can efficiently deliver both small and large RNAs to solid and liquid tumours. Our RBCEVs platform features exceptional merits over conventional RNA delivery methods in biosafety, biocompatibility, efficiency, accessibility, and cost effectiveness.