Microreviews

TRIM16 employs NRF2, ubiquitin system and aggrephagy for safe disposal of stress-induced misfolded proteins

Kautilya Kumar Jena^1,2, Subhash Mehto¹, Srinivasa Prasad Kolapalli¹, Parej Nath¹, Swati Chauhan¹ and Santosh Chauhan¹

We found that under oxidative or proteotoxic stress conditions, the TRIM16 is required for biogenesis of protein aggregates from misfolded proteins. In our attempt to investigate the mechanism by which

p53 and energy balance: meeting hypothalamic AgRP neurons

Omar Al-Massadi^1,2,#, Mar Quiñones^1,2,#, Ruben Nogueiras^1,2

Cancer cells undergo profound metabolic changes to cope with the high energy demand for cell growth and division. Given the importance of this metabolic reprogramming in tumor development, it seems

Attenuating MKRN1 E3 ligase-mediated AMPKα suppression increases tolerance against metabolic stresses in mice

Hyunji Han¹, Sehyun Chae², Daehee Hwang^2,3 and Jaewhan Song¹

The signaling pathways instigated by the activation of AMP-activated protein kinase (AMPK) play major roles in balancing the energy levels in cells as well as in the whole-body system by

Intravital imaging tumor screen used to identify novel metastasis-blocking therapeutic targets

Konstantin Stoletov¹, Lian Willetts¹, Perrin H. Beatty¹ and John D. Lewis¹

INTRODUCTION Currently, many cancer patients undergo chemotherapy, which is aimed at mitigating the risk of future metastasis. These treatments, however, have numerous system-wide off-target effects that negatively impact the patients’

Therapeutic anti-tumor immunity directed against neo-epitopes by intratumor delivery of mRNA encoding MLKL

Lien Van Hoecke^1,2 and Xavier Saelens^1,2,3

We have developed a potentially generic treatment method to induce tumor antigen-specific cellular immunity based on the transient intra-tumor expression of the necroptosis-inducing factor MLKL (Figure 1). Importantly, we have

Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics

Chanh Tin Pham¹, Xin Zhang¹, Austin Lam¹, Minh TN Le¹

The emerging RNA-based therapeutics are renowned for a wide array of druggable targets, which are difficult to achieve by conventional therapies, with high specificity and great versatility. RNA-based drugs function

New insights into the role of soluble E-cadherin in tumor angiogenesis

Maggie K.S. Tang¹, Philip P. Ip² and Alice S.T. Wong¹

Ovarian cancer, the leading cause of death among all gynecological malignancies, is a highly aggressive disease with a propensity for metastasis. Due to the discreet anatomical location, by the time

SKP2 and OTUD1 govern non-proteolytic ubiquitination of YAP that promotes YAP nuclear localization and activity

Fan Yao¹, Zhenna Xiao^1,2, Yutong Sun³ and Li Ma^1,2

YAP and its paralog TAZ are key effectors of the evolutionarily conserved Hippo signaling pathway, a pathway that regulates organ size, tissue homeostasis, and tumorigenesis. In human cells, MST1/2 (mammalian

Irreversible impact of chronic hepatitis C virus infection on human natural killer cell diversity

Benedikt Strunz¹, Julia Hengst^1,2, Heiner Wedemeyer^2,3,4 and Niklas K. Björkström¹

Due to the fact that infection with HCV nearly always becomes chronic, we first investigated the imprint of the persisting infection on the NK cell compartment. To overcome shortcomings of

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