Microreviews
A mutant p53/Hif1α/miR-30d axis reprograms the secretory pathway promoting the release of a prometastatic secretome
Valeria Capaci1,2, Fiamma Mantovani1 and Giannino Del Sal1,2,3
– [table id=357/] MUT-p53 AS A DRIVER OF A MALIGNANT SECRETOME p53 mutants can promote tumorigenesis by affecting fundamental cellular pathways and functions, and by modulating the interplay of cancer
Targeting immune-checkpoint inhibitor resistance mechanisms by MEK inhibitor and agonist anti-CD40 antibody combination therapy
Daniel Baumann1,2 and Rienk Offringa1,2
– [table id=351/] IDENTIFYING SUITABLE CYTOSTATIC DRUGS FOR COMBINATORIAL IMMUNOTHERAPY The main dilemma in finding combinations of cytostatic and immunostimulatory drugs that act synergistically is as follows. On the one
Hyaluronan goes to great length
Vera Gorbunova1, Masaki Takasugi1 and Andrei Seluanov1
The naked mole rat is the longest-lived rodent with the maximum lifespan of over 35 years. Naked mole rats are protected from a wide range of age-related diseases including cancer,
Regulation of immune checkpoint blockade efficacy in breast cancer by FIP200: A canonical-autophagy-independent function
Syn Kok Yeo1 and Jun-Lin Guan1
DISSECTING THE ROLE OF AUTOPHAGY AND AUTOPHAGY-INDEPENDENT FUNCTIONS OF FIP200 IN BREAST CANCER Although initial studies of autophagy genes in cancer implicated a tumor suppressive role, it has become apparent
High mitochondrial calcium levels precede neuronal death in vivo in Alzheimer’s disease
Maria Calvo-Rodriguez1 and Brian J. Bacskai1
MITOCHONDRIAL CALCIUM OVERLOAD AFTER PLAQUE DEPOSITION Ca2+ is essential for the normal function of mitochondrial activity, and therefore Ca2+ levels are tightly regulated in mitochondria. However, excessive levels of Ca2+
Towards understanding the role of Receptor Expression Enhancing Protein 5 (REEP5) in cardiac muscle and beyond
Shin-Haw Lee1,2, Sina Hadipour-Lakmehsari1,2 and Anthony O. Gramolini1,2
DISCOVERY OF REEP5 Cardiac membrane proteins play an important role in regulating normal beat-to-beat function of the heart given their importance in coordinating spontaneous contractions of cardiomyocytes in the heart.
Biomechanical stress regulates mammalian tooth replacement
Xiaoshan Wu1,2 and Songlin Wang1,3
The DT eruption released a biomechanical stress of about 3-20 kPa inside the mandible. By culturing the mandible slice in vitro, the SDL of the PT immediately transitioned into the
Biomechanical stress provides a second hit in the establishment of BMP/TGFβ-related vascular disorders
Christian Hiepen1, Jerome Jatzlau1 and Petra Knaus1
BMPR2 MUTATIONS PRIME FOR PAH BUT REQUIRE A SECOND HIT While BMPR2 mutations appear as one of the main genetic drivers for HPAH, low BMPR2 expression is also found in