Biomechanical stress regulates mammalian tooth replacement
Authors:Xiaoshan Wu1,2 and Songlin Wang1,3
1 Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China.
2 Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
3 Department of Biochemistry and Molecular Biology, Capital Medical University School of Basic Medical Sciences, Beijing 100069, China.
Keywords:
biomechanics, organ replacement, stress, Wnt signaling.
Abbreviations:
DC – deciduous canine;
DT – deciduous tooth;
PT – permanent tooth;
SDL – successional dental lamina.
Corresponding Author(s):
Conflict of interest statement:
The authors declare that they have no conflict of interest.
Please cite this article as:
Xiaoshan Wu and Songlin Wang (2020). Biomechanical stress regulates mammalian tooth replacement. Cell Stress 4(3): 64-65. doi: 10.15698/cst2020.03.215
© 2020 Wu and Wang. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Cyclical renewal of integumentary organs, including hair, feathers, and teeth occurs throughout an organism’s lifetime. Transition from the resting to the initiation stage is critical for each cycle, but the mechanism remains largely unknown. Humans have two sets of dentitions—deciduous and permanent—and tooth replacement occurs only once. Prior to eruption of the permanent tooth (PT), the successional dental lamina (SDL) of the PT can be detected as early as the embryonic stage, even though it then takes about 6–12 years for the SDL to develop to late bell stage. Little is known about the mechanism by which resting SDL transitions into the initiation stage inside the mandible. As a large mammal, the miniature pig, which is also a diphyodont, was a suitable model for our recent study (EMBO J (2020)39: e102374). Using this model, we found that the SDL of PT did not begin the transition into the bud stage until the deciduous tooth (DT) began to erupt.