Publications
Quantifying replication stress in cancer without proliferation confounding
October 28, 2025
The authors developed a refined gene expression signature (TRSS) that accurately measures replication stress independently of cell proliferation, addressing a major limitation of existing biomarkers that conflate stress with oncogene-driven growth. Applying this signature to patient samples, they discovered that replication stress is associated with activation of the non-homologous end-joining DNA repair pathway, suggesting cells may shift toward this repair mechanism under replication stress conditions.
Datopotamab deruxtecan induces hallmarks of immunogenic cell death
August 11, 2025
For full text see pdf.
Oxidative stress induces cortical stiffening and cytoskeletal remodelling in pre-apoptotic cancer cells
August 7, 2025
For full text see pdf.
Role of mitochondrial dysfunction in ocular surface diseases
August 5, 2025
For full text please see pdf.
Bax- Bcl-xL interaction dynamics during the progression of cell cycle and cell death using FLIM-FRET
July 8, 2025
For full text please see pdf.
NFAT5: a stress-related transcription factor with multiple functions in health and disease
May 22, 2025
For full text please see the pdf.
Probiotics and mediterranean diet for breast cancer management and prevention?
May 8, 2025
The human gut microbiota, a diverse community of beneficial normal flora microorganisms, significantly influences physiological function and the immune response. Various microbiota strains have shown promise in supporting clinical treatment of chronic diseases, including cancer, by potentially providing antioxidative and anti-tumorigenic effects in both in vivo and in vitro studies. Breast cancer, which ranks amongst the top five cancer types common worldwide and particularly in Mediterranean countries, has been showing high incidence and prevalence. In breast cancer, microbiota composition, hormonal dynamics, and dietary choices are believed to play significant roles. Hence, the Mediterranean diet, known for its microbiota-friendly features, emerges as a potential protective factor against breast cancer development, highlighting the potential for personalized dietary strategies in cancer prevention. This comprehensive review highlights the emerging mechanisms by (...)