Mitochondrial dynamics links PINCH-1 signaling to proline metabolic reprogramming and tumor growth
How does PINCH-1 regulate proline synthesis? Proline is synthesized in cells through reduction of Δ1-pyrroline-5-carboxylate (P5C) with NAD(P)H as an electron donor, a reaction catalyzed by pyrroline-5-carboxylate reductase (PYCR). Three … Read more