metabolism – Page 2 – Cell Stress

New insights into the key role of HIF-1α in IL-10-producing B cells

HIFs are heterodimeric transcription factors, consisting of an oxygen-labile alpha subunit (HIF- α) and a constitutively-stable beta subunit (HIF-β), that exert pivotal roles in inducing cellular responses to hypoxia. HIF-1α … Read more

VDAC1 at the crossroads of cell metabolism, apoptosis and cell stress

VDAC ISOFORMS, STRUCTURE, AND CHANNEL ACTIVITY VDAC isoforms and cellular localization Three different VDAC isoforms, VDAC1, VDAC2 and VDAC3, sharing ~70% identity and structural and some functional properties [cite]10.1016/j.mam.2010.03.002[/cite][cite]10.1016/j.bbamem.2011.10.005[/cite], are … Read more

TFEB-mTORC1 feedback loop in metabolism and cancer

Everyday most organisms face the requirement to adapt their metabolic cues to the fluctuation of nutrient resources into the environment. When nutrients are abundant cells activate anabolic pathways, such as … Read more