integrated stress response

Burning fat with cysteine depletion

Adams and colleagues comment on two complementary articles by Varghese et al and Lee et al showing that cysteine depletion through combined dietary and genetic means in mice evokes a unique stress response in the liver to amplify these metabolic outcomes and offer a potentially new treatment option for obesity.

Endogenous plasma resuspension of peripheral blood mononuclear cells prevents preparative-associated stress that modiﬁes polyA-enriched RNA responses to subsequent acute stressors

INTRODUCTION Cells are impacted by complex and co-occurring stresses throughout a life-course. Our goal was to generate physiologically relevant models of acute cellular stress, initially in relation to 3’ untranslated … Read more