The NLRC4 inflammasome requires IRF8-dependent production of NAIPs
Authors:Ein Lee1,2, Rajendra Karki1 and Thirumala-Devi Kanneganti1
1 Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
2 Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Keywords:
IRF8, NLRC4, Inflammasome, NAIPs, Salmonella.
Corresponding Author(s):
Conflict of interest statement:
Authors declare no conflict of interest.
Please cite this article as:
Ein Lee, Rajendra Karki and Thirumala-Devi Kanneganti (2018). The NLRC4 inflammasome requires IRF8-dependent production of NAIPs. Cell Stress 2(6): 144-146. doi: 10.15698/cst2018.06.141
© 2018 Lee et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Activation of the NLRC4 inflammasome is crucial for defense against bacterial species that have flagellin or the type III secretion system (T3SS). We have discovered the role of interferon regulatory factor 8 (IRF8) in mediating NLRC4 inflammasome activation. IRF8 is required for the transcription of genes encoding NAIPs, thereby enabling cellular detection of flagellin or T3SS proteins. In vivo, IRF8 is important for NLRC4 inflammasome–dependent cytokine production, bacterial clearance, and ultimately, host survival. By introducing IRF8 as a player in inflammasome regulation, our study provides a new perspective on that process.