Recent progress in the role of autophagy in neurological diseases

Affiliations:

¹ State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University; Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou 511436, China.

² Institute of Neurology, Guangdong Key Laboratory of Age-Related Cardiac-Cerebral Vascular Disease, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China.

³ Department of Biochemistry and Molecular Biology, GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou 511436, People’s Republic of China.

^# These authors contributed equally to this work.

Keywords: 

autophagy, neuro-degenerative diseases, mTOR, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, Amyotrophic lateral sclerosis.

Abbreviatons:

Aβ – amyloid beta,

AD – Alzheimer’s disease,

ALS – amyotrophic lateral sclerosis,

AMPK – AMP-activated protein kinase,

APP – amyloid precursor protein,

ATG – autophagy related,

AV – autophagic vacuole,

C9ORF72 – Chromosome 9 open reading frame 72,

CMA – chaperone-mediated autophagy,

CTF – C-terminal fragment,

ESCRT – endosomal sorting complexes required for transport,

FTD – frontotemporal dementia,

HD – Huntington’s disease,

HTT – huntingtin,

mHTT – mutant HTT,

mTOR – mammalian target of rapamycin,

MVB – multi-vesicular body,

PD – Parkinson’s disease,

PI3K – phosphatidyl inositol 3-kinase, polyQ – poly-glutamine,

VCP – valosin-containing protein.

Corresponding Author(s):

Conflict of interest statement:

The authors declare that they have no conflict of inter-ests.

Please cite this article as:

Tian Meng, Shiyin Lin, Haixia Zhuang, Haofeng Huang, Zhengjie He, Yongquan Hu, Qing Gong and Du Feng (2019). Re-cent progress in the role of autophagy in neurological diseases. Cell Stress 3(5): 141-161. doi: 10.15698/cst2019.05.186

© 2019 Meng et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.