MST kinases in innate immune signaling
Authors:Zhubing Shi1 and Zhaocai Zhou1,2
1 State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
2 School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Keywords:
MST kinases, innate immunity, TLR signaling, antiviral signaling.
Abbreviations:
dsRNA – double-stranded RNA
GCK – germinal center kinase,
HCC – hepatocellular carcinoma,
IFN – interferon,
LPS – lipopolysaccharide,
mROS – mitochondrial ROS
Poly(I:C) – polyinosinic-polycytidylic acid,
RLR – RIG-I-like receptor,
ROS – reactive oxygen species,
STRN – striatin,
TLR – Toll-like receptor.
Corresponding Author(s):
Conflict of interest statement:
The authors have no financial conflict of interest.
Please cite this article as:
Zhubing Shi and Zhaocai Zhou (2017). MST kinases in innate immune signaling. Cell Stress 2(1): 4-13. doi: 10.15698/cst2018.01.119
© 2017 Shi and Zhou. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
The mammalian STE20-like (MST) protein kinases are composed of MST1, MST2, MST3, MST4 and YSK1. They play crucial roles in cell growth, migration, polarity and apoptosis. Dysfunction of these kinases often leads to diseases. MST kinases are extensively involved in development and function of immune system. Here, we review recent progresses on the regulatory function of MST kinases in innate immune signaling.