Mitochondrial stress management: a dynamic journey

Affiliations:

¹ Nestlé Institute of Health Sciences (NIHS), EPFL Innovation Park, 1015 Lausanne.

² School of Life Sciences, EPFL, 1015 Lausanne.

Keywords: 

mitochondria, mitochondrial dynamics, oxidative stress, unfolded protein response, mitophagy, mitochondrial biogenesis.

Abbreviations:

α-KG – α-ketoglutarate,

Aβ – amyloid β peptide,

AMPK – AMP-activated protein kinase,

AP – autophagosome,

CAT – catalase,

CHOP – C/EBP homologous protein,

CLPP - ATP-dependent caseinolytic protease proteolytic subunit,

COX - cytochrome C oxidase,

ER – endoplasmic reticulum,

GPx – glutathione peroxidases,

IMM – inner mitochondrial membrane,

IMS – intermembrane space,

ISR – integrated stress response,

MDP – mitochondrial derived peptide,

MSR – mitochondrial stress response,

mtDNA – mitochondria DNA,

OMM – outer mitochondrial membrane,

OXPHOS – oxidative phosphorylation,

PERK – protein kinase RNA-like ER kinase,

PGC-1α – Peroxisome Proliferator Activator Receptor Gamma Coactivator 1a,

PINK1 – PTEN-induced putative kinase 1,

ROS – reactive oxygen species,

SOD – superoxide dismutase,

TCA – tricarboxylic acid cycle,

TrRx – Thioredoxin reductases,

UPR – unfolded protein response,

ΔΨm – mitochondrial membrane potential.

Corresponding Author(s):

Conflict of interest statement:

MV‐A and CC are employees of the Nestlé Institute of Health Sciences S.A.

Please cite this article as:

Miriam Valera-Alberni and Carles Canto (2018). Mitochondrial stress management: a dynamic journey. Cell Stress 2(10): 253-274. doi: 10.15698/cst2018.10.158

© 2018 Valera-Alberni and Canto. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.