Mitochondrial dysfunction and its role in tissue-specific cellular stress

Authors:

David Pacheu-Grau1, Robert Rucktäschel1 and Markus Deckers1
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Affiliations:

1 Department of Cellular Biochemistry, University Medical Center Göttingen, Germany.

Keywords: 

mitochondrial dysfunction, cellular stress, mitochondrial pathology, therapy.

Corresponding Author(s):

David Pacheu-Grau, University Medical Center Göttingen, Department of Cellular Biochemistry, Humboldtallee 23, 37073 Göttingen, Germany. Phone: +49-(0)551-394571 David.Pacheu-Grau@med.uni-goettingen.de Markus Deckers, University Medical Center Göttingen, Department of Cellular Biochemistry, Humboldtallee 23, 37073 Göttingen, Germany. Phone: +49-(0)551-395983 Markus.Deckers@medizin.uni-goettingen.de

Conflict of interest statement:

The authors declare no conflict of interest.

Please cite this article as:

David Pacheu-Grau, Robert Rucktäschel and Markus Deckers (2018). Mitochondrial dysfunction and its role in tissue-specific cellular stress. Cell Stress 2(8): 184-199. doi: 10.15698/cst2018.07.147

© 2018 Pacheu-Grau et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.

Abstract:

Mitochondrial bioenergetics require the coordination of two different and independent genomes. Mutations in either genome will affect mitochondrial functionality and produce different sources of cellular stress. Depending on the kind of defect and stress, different tissues and organs will be affected, leading to diverse pathological conditions. There is no curative therapy for mitochondrial diseases, nevertheless, there are strategies described that fight the various stress forms caused by the malfunctioning organelles. Here, we will revise the main kinds of stress generated by mutations in mitochondrial genes and outline several ways of fighting this stress.