The missing hallmark of health: psychosocial adaptation

Affiliations:

¹ Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.

² Facultad de Ciencias de la Vida y la Naturaleza, Universidad Nebrija, Madrid, Spain.

³ Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo.

⁴ Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.

⁵ Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.

Keywords: 

mental health, aging, psychiatry, psychology.

Abbreviations:

Arc – activity-regulated cytoskeleton-associated protein;

ASD – autistic spectrum disorders;

BBB – blood-brain barrier;

BD – bipolar disorder;

C4A – component 4A;

CLDN5 – claudin-5;

CNS – central nervous system;

CSF1R – colony stimulating factor 1 receptor;

DDR – DNA damage response;

DISC1 – disrupted-in-SCZ-1;

EBP1 – ErbB3-binding protein 1;

FMRP1 – fragile X mental retardation protein 1;

FOXO1 – forkhead box protein O1;

GSK-3α – glycogen synthase kinase 3α;

HDAC1 – histone deacetylase 1;

HPA – hypothalamic pituitary adrenal;

IL6 – interleukin-6;

iPSC – induced pluripotent stem cell;

MDD – major depressive disorder;

mtDNA – mito-chondrial DNA;

NLGN3 – neuroligin-3;

NPY – neuropeptide Y;

ROS – reactive oxygen species;

S1PR3 – sphingosine-1-phosphate receptor 3;

SAM – sympathetic-adrenal medullary;

SCZ – schizophrenia;

Tac2 – tachykinin 2;

WHO – world health organization.

Corresponding Author(s):

Conflict of interest statement:

G.K. has been holding research contracts with Daiichi Sankyo, Eleor, Kaleido, Lytix Pharma, PharmaMar, Osasuna Therapeutics, Samsara Therapeutics, Sanofi, Tollys, and Vascage. G.K. is on the Board of Directors of the Bristol Myers Squibb Foundation France. G.K. is a scientific co-founder of everImmune, Osasuna Thera-peutics, Samsara Therapeutics and Therafast Bio. G.K. is in the scientific advisory boards of Hevolution, Institut Servier and Longevity Vision Funds. G.K. is the inventor of patents covering therapeutic targeting of aging, can-cer, cystic fibrosis and metabolic disorders. G.K.’s wife, Laurence Zitvogel, has held research contracts with Glaxo Smyth Kline, Incyte, Lytix, Kaleido, Innovate Phar-ma, Daiichi Sankyo, Pilege, Merus, Transgene, 9 m, Tusk and Roche, was on the on the Board of Directors of Transgene, is a cofounder of everImmune, and holds patents covering the treatment of cancer and the thera-peutic manipulation of the microbiota. G.K.’s brother, Romano Kroemer, was an employee of Sanofi and now consults for Boehringer-Ingelheim.

Please cite this article as:

Carlos López-Otín and Guido Kroemer (2024). The miss-ing hallmark of health: psychosocial adaptation. Cell Stress 8: 21-50. doi: 10.15698/cst2024.03.294

© 2024 López-Otín and Kroemer. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.