Macrolide antibiotics activate the integrated stress response and promote tumor proliferation

Affiliations:

¹ Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, P. R. China.

² Gustave Roussy Cancer Campus, Villejuif Cedex, France.

³ Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France.

⁴ Centre de Recherche des Cordeliers, INSERM U1138, Équipe Labellisée – Ligue Nationale contre le Cancer, Université Paris Cité, Sorbonne Université, Paris, France.

⁵ Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France.

⁶ Medical College, Anhui University of Science and Technology, Huainan, AnHui, P. R. China.

⁷ Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei, P. R. China.

⁸ Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, P. R. China.

⁹ Tongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.

^# These authors have contributed equally to this work and share first authorship.

Keywords: 

macrolide antibiotic, azithromycin, autophagy, ROS, ER stress, cancer.

Abbreviations:

AZD – azithromycin;

Baf A1 – Bafilomycin A1;

CHOP – C/EBP homologous protein;

eIF2α – eukaryotic initiation Factor 2α;

EMT - epithelial-mesenchymal transition;

ER – endoplasmic reticulum;

GFP – green fluorescent protein;

ISR – integrated stress response;

NAC – N-acetylcysteine;

PERK – PKR-like ER kinase;

PKR – protein kinase double-stranded RNA-dependent;

RA – roxithromycin;

ROS – reactive oxygen species;

SP – spiramycin;

TFE3 – transcription factor E3;

TFEB – transcription factor EB;

TG – thapsigargin;

TM – tunicamycin;

UPR – unfolded protein response.

Corresponding Author(s):

Conflict of interest statement:

All the authors agree to the submission and consent for publication this paper. The authors have declared that no competing interest exists.

Please cite this article as:

Xin Yu, Ai-Ling Tian, Ping Wang, Juanjuan Li, Juan Wu, Bei Li, Zhou Liu, Siqing Liu, Zhijie Gao, Si Sun, Shengrong Sun, Yi Tu and Qi Wu (2023). Macrolide antibiotics activate the inte-grated stress response and promote tumor proliferation. Cell Stress 7(4): 20-33. doi: 10.15698/cst2023.04.278

© 2023 Yu et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.