Pyroptosis in NLRP3 inflammasome-related atherosclerosis
Authors:Xiang Zeng1,#, Dongling Liu2,3,#, Xia Huo4, Yue Wu1, Cuiqing Liu1, Qinghua Sun1
1 School of Public Health, International Science and Technology Cooperation Base of Air Pollution and Health, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, Zhejiang Province, China.
2 School of Basic Medical Science, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, Zhejiang Province, China.
3 First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China.
4 Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, Guangdong Province, China.
# These authors contributed equally to this work.
Keywords:
NLRP3 inflammasome, caspase-1, GSDMD, IL-1β, pyroptosis, atherosclerosis, cardiovascular diseases.
Corresponding Author(s):
Conflict of interest statement:
The authors declare that they have no conflict of interest.
Please cite this article as:
Xiang Zeng, Dongling Liu, Xia Huo, Yue Wu, Cuiqing Liu, Qinghua Sun (2022). Pyroptosis in NLRP3 inflammasome-related atherosclerosis. Cell Stress 6(10): 79-88. doi: 10.15698/cst2022.10.272
© 2022 Zeng et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Pyroptosis is a proinflammatory form of programmed cell death in response to inflammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro-inflammatory mediator and cytokine release. There are known pyroptosis molecular pathways including the caspase-1 depended canonical signaling pathway and the caspase-4/5/11 determined non-canonical signaling pathway. It is essential to explore the connection among NLRP3 inflammasome, pyroptosis and atherosclerosis, which may shed light on the potential therapeutic strategies that target pyroptosis in atherosclerotic treatment.