Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health

Affiliations:

¹ Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain.

² Universiteit van Amsterdam, Amsterdam, The Netherlands.

Keywords: 

neurodevelopment, developmental disorders, neuronal autophagy, autism spectrum disorder, neurogenesis.

Abbreviatons:

AMPK – AMP activated protein kinase;

ASD – autism spectrum disorder;

ATG – autophagy-related;

BPAN – β-propeller protein-associated neurodegeneration;

CMA – chaperone-mediated autophagy;

CNS – central nervous system;

ER – endoplasmic reticulum;

FXS – Fragile X syndrome; HSP – hereditary spastic paraplegia;

ID – intellectual disability;

IM – isolation membrane;

KO – knockout;

LAMP2 – lysosome-associated membrane protein 2;

LC – light chain;

LDD – Lhermitte-Duclos disease;

mTOR – mechanistic target of rapamycin;

mTORC – mTOR complex;

NSC – neuronal stem cell;

PI3K – phoshatidylinositol 3- kinase;

PI3P – phosphatidylinositol 3-phosphate;

POMC – proopiomelanocortin;

TSC – tuberous sclerosis complex;

ULK1 – UNC51-like kinase 1.

Corresponding Author(s):

Conflict of interest statement:

The author’s declare no conflict of interest.

Please cite this article as:

Juan Zapata-Muñoz, Beatriz Villarejo-Zori, Pablo Largo-Barrientos and Patricia Boya (2021). Towards a better understand-ing of the neurodevelopmental role of autophagy in sickness and in health. Cell Stress 5(7): 99-118. doi: 10.15698/cst2021.07.253

© 2021 Zapata-Muñoz et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and re-production in any medium, provided the original author and source are acknowledged.