Improving glucose and lipids metabolism: drug development based on bile acid related targets

Affiliations:

¹ School of Pharmacy, Fudan University, Shanghai 201203, China.

² Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

³ Department of Diabetes Complications and Metabolism, Institute of Diabetes and Metabolism Research Center, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA.

⁴ Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Keywords: 

bile acid, FXR, TGR5, GPBAR1, bile salt hydrolase, CYP8B1.

Abbreviatons:

6-ECDCA – 6α-ethyl-chenodeoxycholic acid;

BSH – bile salt hydrolase;

BTA – betulinic acid;

CA – cholic acid;

CDCA – chenodesoxycholic acid;

DHA – dihydroartemisinin;

DPP-4 – dipeptidyl peptidase-4;

FXR – farnesoid X receptor;

GLP-1 – glucagon-like peptide-1;

HFD – high-fat diet;

LCA – lithocholic acid;

MCA – muricholic acid;

miR-26a – microRNA-26a;

NAFLD – nonalcoholic fatty liver disease;

NASH – nonalcoholic steatohepatitis;

OA – oleanolic acid;

PBC – primary biliary cholangitis;

PEG – polyethylene glycol;

PYY – peptide YY;

RYGB – Roux-en-Y gastric bypass;

SAR – structure-activity relationship;

TβMCA – tauro-β-muricholic acid;

TCA – tauro-cholic acid;

TGR5 – Takeda G-protein-coupled receptor 5;

TLCA – taurolithocholic acid;

UDCA – ursodeoxycholic acid;

VSG – vertical sleeve gastrectomy.

Corresponding Author(s):

Conflict of interest statement:

The authors declare no conflicts of interest.

Please cite this article as:

Hanchen Shen, Lili Ding, Mehdi Baig, Jingyan Tian, Yang Wang and Wendong Huang (2021). Improving glucose and lipids metabolism: drug development based on bile acid related targets. Cell Stress 5(1): 1-18. doi: 10.15698/cst2021.01.239

© 2021 Korenkova et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.