Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases

Affiliations:

¹ Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.

² Kither Biotech S.r.l. Via Nizza 52, 10126, Torino, Italy.

^# Equal contribution to senior authorship

Keywords: 

PI3K signaling, chronic respiratory disease, restrictive airway disease, obstructive airway disease, inflammation.

Abbreviatons:

AHR – airway hyperresponsiveness;

ASM – airway smooth muscle;

cAMP – cyclic adenosine monophosphate;

CF – cystic fibrosis;

CFTR – CF transmembrane conductance regulator;

GPCR – G-protein coupled receptor;

COPD – chronic obstructive pulmonary disease;

IAV – influenza A;

IFN – interferon;

IL – interleukin;

IPF – idiopathic pulmonary fibrosis;

KD – knockdown;

KO – knockout;

LPS – lipopolysaccharide;

MIF – migration inhibitory factor;

NK – natural killer;

PI3K – phosphatidyl inositol 3 kinase;

PLY – pneumolysin;

SNP - single-nucleotide polymorphisms;

TLR – Toll-like receptor;

VILI – ventilation-induced lung injury.

Corresponding Author(s):

Conflict of interest statement:

Alessandra Ghigo and Emilio Hirsch are founders of Kither Biotech S.r.l. Valentina Sala received a contract fee from Kither Biotech S.r.l.

Please cite this article as:

Valentina Sala, Angela Della Sala, Alessandra Ghigo and Emilio Hirsch (2021). Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases. Cell Stress 5(4): 40-51. doi: 10.15698/cst2021.04.246

© 2021 Sala et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.