Cellular mechanisms linking cancers to obesity

Affiliations:

¹ Department of Biomedicine, University of Bergen, N-5020 Bergen, Norway.

^# Equal contribution.

Keywords: 

obesity, cancer, mouse models, adipokines, metabolism, inflammation, extracellular Matrix remodeling.

Abbreviatons:

ARG2 – arginase 2;

BMI – body mass index;

COX2 – cyclooxygenase-2;

DIO – diet-induced obesity;

ECM – extracellular matrix;

FABP – fatty acid binding protein;

FACS – fluorescence-activated cell sorting;

FFA – free fatty acid;

HCC – hepatocellular carcinoma;

HFD – high-fat diet;

IGF – insuline growth factor;

IL – interleukin;

LFD – low-fat diet;

MMTV – mouse mammary tumor virus;

NASH – non-alcoholic steatohepatitis;

PDAC – pancreatic ductal adenocarcinoma;

PPARγ – peroxisome proliferator-activated receptor γ;

PyMT – polyoma middle T antigen;

S1P – sphingosine-1-phosphate;

SCFA – short-chain fatty acid;

TGFα – transforming growth factor-alpha;

TNFα – tumor necrosis factor-α.

Corresponding Author(s):

Conflict of interest statement:

The authors declare no competing interests.

Please cite this article as:

Xiao-Zheng Liu, Line Pedersen and Nils Halberg (2021). Cellular mechanisms linking cancers to obesity. Cell Stress 5(5): 55-72. doi: 10.15698/cst2021.05.248

© 2021 Liu et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.