Atg8ylation as a general membrane stress and remodeling response

Affiliations:

¹ Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

² Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

Keywords: 

ubiquitylation, endosome, exosomes, microvesicles, secretory autophagy, unconventional secretion, secretion, ubiquitin, galectin, lap, lc3, atg8, tfeb, lysosome, ampk, mtor, autophagy.

Abbreviatons:

AIM – Atg8-interacting motif;

EV – extracellular vesicle;

ILV – intralumenal vesicle;

LANDO – LC3-associated endocytosis;

LAP – LC3-associated phagocytosis;

LIR – LC3 interacting region;

mAtg8s – mammalian Atg8s;

mTOR – mechanistic target of rapamycin;

PAMP – pathogen associated molecular pattern;

PE – phosphatidylethanolamine;

PS – phosphatidylserine;

ROS – reactive oxygen species; SLR – sequestosome-like receptor;

TFEB – transcription factor EB;

TLR- Toll-like receptor;

UPS – ubiquitin proteasome system.

Corresponding Author(s):

Conflict of interest statement:

The authors declare no conflict of interest.

Please cite this article as:

Suresh Kumar, Jingyue Jia and Vojo Deretic (2021). Atg8ylation as a general membrane stress and remodeling re-sponse. Cell Stress 5(9): 128-142. doi: 10.15698/cst2021.09.255

© 2021 Kumar et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.