Building and breaking the gut barrier with bariatric surgery

Authors:

Mohammed K. Hankir1
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Affiliations:

1 Department of Experimental Surgery, University Hospital Wuerzburg, Wuerzburg, 97080, Germany.

Keywords: 

bariatric surgery, gut barrier, gut microbiota, insulin resistance, endotoxemia.

Corresponding Author(s):

Dr. Mohammed K. Hankir, Center of Operative Medicine, Oberduerrbacherstrasse 6, 97080 Wuerzburg, Germany; Phone: +49 931 201 31728; hankir_m@ukw.de

Conflict of interest statement:

The author has no conflicts of interest to declare.

Please cite this article as:

Mohammed K. Hankir (2021). Building and breaking the gut barrier with bariatric surgery. Cell Stress 6(2): 17-20. doi: 10.15698/cst2022.02.263

© 2021 Hankir. This is an open-access article released under the terms of the Creative Com-mons Attribution (CC BY) license, which allows the unre-stricted use, distribution, and reproduction in any medi-um, provided the original author and source are acknowledged.

Abstract:

Bariatric surgery has been proposed to improve glycemic control in morbidly obese patients by stabilising the gut barrier and alleviating endotoxemia-induced insulin resistance. Here, recent studies are highlighted which reveal site-specific and at times opposing effects of bariatric surgery on the gut barrier. Further understanding the underlying mechanisms may not only inform the development of novel gut-based drugs for the initial treatment of type 2 diabetes, but possibly also assist in the management of its eventual relapse.