Endocytosis in the adaptation to cellular stress
Authors:Tania López-Hernández1, Volker Haucke1,2 and Tanja Maritzen1
1 Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
2 Freie Universität Berlin, Faculty of Biology, Chemistry, Pharmacy, 14195 Berlin, Germany.
Keywords:
clathrin-mediated endocytosis; cancer; nutrient signaling; osmotic stress; mechanical stress; hypoxia; oxidative stress.
Abbreviatons:
AMPK – AMP-activated kinase,
Bsep – bile salt export pump,
CME – Clathrin-mediated endocytosis,
EGFR – epidermal growth factor receptor,
ENaC – epithelial sodium channel,
GDI – guanyl-nucleotide dissociation inhibitor,
GPCR – G-protein coupled receptor,
HIF – Hypoxia inducible factor,
LDL – low density lipoprotein,
LDLR – LDL receptor,
OGD – oxygen and glucose deprivation,
ROS – reactive oxygen species.
Corresponding Author(s):
Conflict of interest statement:
The authors declare no conflicts of interest.
Please cite this article as:
Tania López-Hernández Volker Haucke and Tanja Maritzen (2020). Endocytosis in the adaptation to cellular stress. Cell Stress 4(10): 230-247. doi: 10.15698/cst2020.10.232
© 2020 López-Hernández et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and re-production in any medium, provided the original author and source are acknowledged.
Abstract:
Cellular life is challenged by a multitude of stress conditions, triggered for example by alterations in osmolarity, oxygen or nutrient supply. Hence, cells have developed sophisticated stress responses to cope with these challenges. Some of these stress programs such as the heat shock response are understood in great detail, while other aspects remain largely elusive including potential stress-dependent adaptations of the plasma membrane proteome. The plasma membrane is not only the first point of encounter for many types of environmental stress, but given the diversity of receptor proteins and their associated molecules also represents the site at which many cellular signal cascades originate. Since these signaling pathways affect virtually all aspects of cellular life, changes in the plasma membrane proteome appear ideally suited to contribute to the cellular adaptation to stress. The most rapid means to alter the cell surface proteome in response to stress is by alterations in endocytosis. Changes in the overall endocytic flux or in the endocytic regulation of select proteins conceivably can help to counteract adverse environmental conditions. In this review we summarize recent data regarding stress-induced changes in endocytosis and discuss how these changes might contribute to the cellular adaptation to stress in different systems. Future studies will be needed to uncover the underlying mechanisms in detail and to arrive at a coherent picture.