PRMT5 function and targeting in cancer

Affiliations:

¹ Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.

Keywords: 

PRMT5, PRMT1, histone, transcription, splicing, MEP50, methylation, methyltransferase.

Abbreviatons:

aDMA – asymmetric dimethylarginine;

AML – acute myeloid leukemia;

AR – androgen receptor;

CSC – cancer stem cell;

DDR – DNA damage response;

DSB – double strand break;

HCC – hepatocellular carcinoma;

HR – homologous recombination;

ICT – immune checkpoint therapy;

KO – knockout;

lncRNA – long noncoding RNA;

me1 – monomethylation;

m2a – asymmetric demethylation;

m2s – symmetric demethylation;

MMA – monomethylarginine;

MTA – methylthioadenosine;

MTAP – MTA phosphorylase;

PC – prostate cancer;

PDGF – platelet derived growth factor;

PHD – plant homeodomain;

PRMT – protein arginine methyltransferase;

PTM – posttranslational modification;

SAM – S-adenosylmethionine;

sDMA – symmetric dimethylarginine;

snRNP – small nuclear ribonucleoprotein particle;

TCR – T cell receptor;

Treg – regulatory T cell.

Corresponding Author(s):

Conflict of interest statement:

ZR is a co-founder and serves as scientific advisor to Pangea Therapeutics. HK declares no competing inter-ests.

Please cite this article as:

Hyungsoo Kim and Ze’ev A. Ronai (2020). PRMT5 func-tion and targeting in cancer. Cell Stress 4(8): 199-215. doi: 10.15698/cst2020.08.228

© 2020 Kim and Ronai. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.