The role of lipids in autophagy and its implication in neurodegeneration

Affiliations:

¹ Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, 33000, Bordeaux, France.

² CNRS, Institut des Maladies Neurodégénératives, UMR 5293, 33000, Bordeaux, France.

Keywords: 

autophagy, neurodegeneration, lipids, sphingolipids, phosphoinositols, Parkinson’s disease, Alzheimer’s disease. Abbreviatons:

Aβ – amyloid beta;

AD – Alzhheimer’s disease;

APP – amyloid precursor protein;

ASM – acid SMase;

C1P – Cer-1-phosphate;

Cer – ceramide;

EAP – ethanolamine phosphate;

ER – endoplasmic reticulum;

GABARAP – γ-aminobutyric acid receptor-associated protein;

GBA – glucocerebrosidase;

GCS – GlcCer synthase;

GlcCer – glucosylceramide;

GUV – giant unilamellar vesicle;

HD – Huntington’s disease;

iPSC – induced pluripotent stem cell;

KO – knockout;

LC3 – light chain 3;

LSD – lysosomal storage disorder;

LYNUS – lysosomal nutrient-sensing complex;

MTM – myotubularin phosphatase family;

mTOR – mammalian target of rapamycin;

PD – Parkinson’s disease;

PE – phosphatidylethanolamine;

PI – phosphatidylinositol;

PI3K – PI-3 kinase;

PI3P – PI-3 phosphate;

PICALM – PI binding clathrin assembly protein;

polyQ – polyglutamine;

S1P – sphingosine‑1‑phosphate;

SM – sphingomyelin;

SMase – sphingomyelinase;

Sph – sphingosine;

SphK – Sph kinase;

TFEB – transcription factor EB.

Corresponding Author(s):

Conflict of interest statement:

The authors declare no conflict of interest.

Please cite this article as:

Sergio Hernandez-Diaz and Sandra-Fausia Soukup (2020). The role of lipids in autophagy and its implication in neuro-degeneration. Cell Stress 4(7): 167-186. doi: 10.15698/cst2020.07.225

© 2020 Hernandez-Diaz and Soukup. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and re-production in any medium, provided the original author and source are acknowledged.