A sympathetic gut connection drives the metabolic benefits of Roux-en-Y gastric bypass
Authors:Mohammed K. Hankir1
Department of Experimental Surgery, University Hospital Wuerzburg, Wuerzburg, 97080, Germany.
Keywords:
Roux-en-Y gastric bypass, sleeve gastrectomy, resting metabolic rate, thermogenesis, splanchnic nerve, mesenteric white fat browning, weight loss, cannabinoid 1 receptor.
Abbreviatons:
CB1 – cannabinoid 1;
RYGB – Roux-en-Y gastric bypass;
SG – sleeve gastrectomy;
TH – tyrosine hydroxylase;
UCP1 – uncoupling protein 1.
Corresponding Author(s):
Conflict of interest statement:
The author has no conflict of interests to declare.
Please cite this article as:
Mohammed K. Hankir (2020). A sympathetic gut connection drives the metabolic benefits of Roux-en-Y gastric bypass. Cell Stress 4(12): 265-269. doi: 10.15698/cst2020.12.236
© 2020 Hankir. This is an open-access article released under the terms of the Creative Com-mons Attribution (CC BY) license, which allows the unre-stricted use, distribution, and reproduction in any medi-um, provided the original author and source are acknowledged.
Abstract:
Surgery is regarded by many as the go-to treatment option for severe obesity; yet how physically altering the gastrointestinal tract produces such striking results on body weight and overall metabolic health is poorly understood. In a recent issue of Cell Reports Ye et al. (2020) compare mouse models of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), the two most commonly performed weight loss surgeries in the clinic today, to show that the former reconfiguring procedure selectively increases resting metabolic rate through splanchnic nerve-mediated browning of mesenteric white fat. More significantly, they demonstrate that this effect for RYGB is required for the maintained negative energy balance and improved glycemic control that it confers.