Mitochondria in cancer

Affiliations:

¹ Pole of Pharmacology & Therapeutics, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium.

Keywords: 

tumor metabolism, tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS), reactive oxygen species (ROS), apoptosis, mitophagy, mitochondrial biogenesis.

Abbreviatons:

2DG – 2-deoxy-D-glucose;

2HG – D-2-hydroxyglutarate;

3BP – 3-bromopyruvate;

α-KG – α-ketoglutarate;

α-TOS – α-tocopheryl succinate; ACO2 – aconitase 2;

AML – acute myeloid leukemia;

AMPK – AMP kinase;

Atg - autophagy-related;

Bcl-2 – B-cell lymphoma 2;

CoQ – coenzyme Q;

CS - citrate synthase;

CSC – cancer stem cell; DRP1 – dynamin-related protein 1;

EMT – epithelial to mesenchymal transition;

EOC – epithelial ovarian carcinoma;

ER – endoplasmic reticulum;

ETC – electron transport chain;

FAO – fatty acid oxidation;

FH – fumarate hydratase;

FoxO1 – forkhead O family protein 1;

FUNDC1 – FUN14 domain-containing 1;

GAPDH – glyceraldehyde-3-phosphate dehydrogenase;

GLUT – glucose transporter;

GSH – glutathione;

GST – glutathione S-transferase;

HIF – hypoxia-inducible factor;

HK – hexokinase;

Hsp70 – heat shock protein 70;

IDH – isocitrate dehydrogenase;

IMM – inner mitochondrial membrane;

IMS – intermembrane space;

KD – ketogenic diet;

KRAS – V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog;

LC3 – microtubule-associated protein light chain 3;

LDH-1 – lactate dehydrogenase-1;

MAVS – mitochondrial anti-viral signaling;

MCL-1 – myeloid leukemia cell differentiation protein-1;

Mdivi-1 – mitochondrial division inhibitor-1;

Mff – mitochondrial fission factor;

Mfn – mitofusin;

mtDNA – mitochondrial DNA;

mtROS - mitochondrial ROS;

mtSNP – single nucleotide polymorphism in mtDNA;

Nrf2 – nuclear factor erythroid-derived 2-like 2;

OMM – outer mitochondrial membrane;

Opa1 – optic atrophy protein 1;

OXPHOS – oxidative phosphorylation;

PDT – photodynamic therapy;

PEP – phosphoenolpyruvate;

PKA – cAMP-activated protein kinase A;

PINK1 – phosphatase and tensin homolog-induced kinase 1;

PTEN – phosphatase and tensin homolog;

ROS – reactive oxygen species;

SCO2 – synthesis of cytochrome oxidase 2;

SDH – succinate dehydrogenase;

Sirt – sirtuin;

SOD – superoxide dismutase;

TCA – tricarboxylic acid (cycle);

TERT – telomerase reverse transcriptase;

TGFβ – transforming growth factor β;

TIGAR – TP53-induced glycolysis and apoptosis regulator;

TNT – tunneling nanotube;

VDAC – voltage-dependent anion channel.

Corresponding Author(s):

Conflict of interest statement:

The authors declare no conflict of interest.

Please cite this article as:

Debora Grasso, Luca X Zampieri, Tânia Capelôa, Justine A. Van de Velde and Pierre Sonveaux (2020). Mitochondria in cancer. Cell Stress 4(6): 114-146. doi: 10.15698/cst2020.06.221

© 2020 Grasso et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.