Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

Affiliations:

¹ Department of Pathology and Immunology, Targeting of Cytokine Secreting Lymphocyte group, Geneva University, Geneva, Switzerland.

² Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Switzerland.

³ Departamento de Microbiología, Grupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Bogotá, Colombia.

Keywords: 

natural products, cancer, immune response, network pharmacology, immunomodulation, herbal medicine, immunogenic cell death.

Abbreviations:

CRT – calreticulin;

DAMP – damage associated molecular pattern;

DC – dendritic cell;

DMIM – Distance-based Mutual Information Model;

ER – endoplasmic reticulum;

HCV – hepatitis C virus;

ICD – immunogenic cell death;

JTT – juzen-taiho-to;

NK – natural killer;

NP – network pharmacology;

PDT – photodynamic therapy;

ROS – reactive oxygen species;

SK – shikonin;

TCM – Traditional Chinese Medicine;

UPR – unfolded protein response.

Corresponding Author(s):

Conflict of interest statement:

None of the authors declares any conflict of interest.

Please cite this article as:

Alejandra Gomez-Cadena, Alfonso Barreto, Susana Fiorentino and Camilla Jandus (2020). Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment. Cell Stress 4(7): 154-166. doi: 10.15698/cst2020.07.224

© 2020 Gomez-Cadena <iet al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and re-production in any medium, provided the original author and source are acknowledged.