Could de-stressing the brain be the solution for long-term weight loss?

Affiliations:

¹ Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, 97080 Bavaria, Germany.

² Department of Experimental Surgery, University Hospital Wuerzburg, Wuerzburg, 97080 Bavaria, Germany.

Keywords: 

endoplasmic reticulum stress, gliosis, hypothalamus, inflammation, leptin resistance, obesity, vertical sleeve gastrectomy.

Abbreviations:

eIF2a – elongation initiation factor 2 alpha,

ER – endoplasmic reticulum,

FXR – farnesoid X receptor,

GABA – gamma amino butyric acid,

GLP-1 – glucagon-like peptide 1,

IKK-β – inhibitor of kappa beta kinase beta,

IL – interleukin,

HSF1 – heat shock factor 1,

NF-Кβ – necrosis factor kappa beta,

PERK – protein kinase R (PKR)-like ER kinase,

PTP1B – protein tyrosine phosphatase 1B,

PGC-1α – peroxisome proliferator-activated receptor gamma coactivator 1-alpha,

SOCS3 – suppressor of cytokine signaling 3,

TGR5 – Takeda G-protein 5 receptor,

TLR4 – toll-like receptor 4,

TNF-α – tumor necrosis factor alpha,

UCP1 – uncoupling protein 1,

VSG – vertical sleeve gastrectomy,

vWAT – visceral white adipose tissue.

Corresponding Author(s):

Conflict of interest statement:

The authors have no conflicts of interest to declare.

Please cite this article as:

Florian Seyfried and Mohammed K. Hankir (2019). Could de-stressing the brain be the solution for long-term weight loss? Cell Stress 3(2): 29-37. doi: 10.15698/cst2019.02.174

© 2019 Seyfried and Hankir. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.