The role of epigenetics in hypothalamic energy balance control: implications for obesity

Affiliations:

¹ Neuronal Control of Metabolism Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.

² Centro de Investigación Biomédica en Red (CIBER) de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 08036 Barcelona, Spain.

Keywords: 

obesity, hypothalamus, epigenetic, energy balance, AgRP neurons, POMC neurons.

Abbreviatons:

5-mC – 5-methylcytosine,

α-MSH – α-melanocyte-stimulating hormone,

AgRP – agouti-related protein,

AMPK – AMP-activated protein kinase,

ARC – arcuate nucleus,

DNMT – DNA methyltransferases,

GABA – γ-aminobutyric acid,

GWAS – genome-wide association studies,

HAT – histone acetyltransferase,

HDAC – histone deacetylase,

LH – lateral hypothalamus,

lncRNA – long ncRNA,

MCR – melanocortin receptor,

miRNA – micro RNA,

mRNA – messenger RNA,

ncRNA – non-coding RNA,

NPY – neuropeptide Y,

POMC – pro-opimelanocortin,

PTM – post-translational modification,

PVN – paraventricular nucleus,

snoRNA – small nucleolar RNA,

snRNA – small nuclear RNA,

T2D – type 2 diabetes,

VMH – ventromedial hypothalamus.

Corresponding Author(s):

Conflict of interest statement:

The authors declare no competing interests.

Please cite this article as:

Arnaud Obri and Marc Claret (2019). The role of epige-netics in hypothalamic energy balance control: implications for obesity. Cell Stress 3(7): 208-220. doi: 10.15698/cst2019.07.191

© 2019 Obri and Claret. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.