Publications
The long non-coding RNA H19 – a new player in hepatocellular carcinoma
October 1, 2017
Hepatocellular carcinoma (HCC) is among the most prevalent and lethal cancers worldwide [cite]10.3322/caac.20107[/cite]. Incidence is increasing and due to its high chemoresistance, the therapeutic options are limited and HCC has
mIDH-associated DNA hypermethylation in acute myeloid leukemia reflects differentiation blockage rather than inhibition of TET-mediated demethylation
September 20, 2017
INTRODUCTION Isocitrate dehydrogenase enzymes IDH1 and IDH2 are two closely related enzymes that convert isocitrate to α-ketoglutarate in the tricarboxylic acid (TCA) cycle. The genes encoding IDH1 and IDH2 are
Senescence explains age- and obesity-related liver steatosis
September 19, 2017
In a study recently published in the journal Nature Communications we have researched the role of cellular senescence during liver ageing, in obesity and NAFLD. We observed that hepatocyte fat
The long non-coding RNA H19 suppresses carcinogenesis and chemoresistance in hepatocellular carcinoma
August 25, 2017
The long non-coding RNA (lncRNA) H19 represents a maternally expressed and epigenetically regulated imprinted gene product and is discussed to have either tumor-promoting or tumor-suppressive actions. Recently, H19 was shown to be regulated under inflammatory conditions. Therefore, aim of this study was to determine the function of H19 in hepatocellular carcinoma (HCC), an inflammation-associated type of tumor. In four different human HCC patient cohorts H19 was distinctly downregulated in tumor tissue compared(...)