Research Articles

Glycemia reprograms substrate transport and shapes divergent stress responses in differentiating H9c2 cells

Sofia Passaponti1, Asia Iserani2, Roberta Romagnoli2, Laura Cresti2, Cinzia Del Gaudio2, Alice Luddi3, Leonardo Ermini2 and Francesca Ietta2

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Triptolide inhibits ovarian cancer growth and metastasis via reprogramming of tumor-associated macrophages

Ziqi Chen1,2,a, Jie Zhang3,a, Jianting Lao4, Chaoqin Yu5 and Hong Yang1,4

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The IRE1α-XBP1s-NFκB axis controls cell survival and epithelial differentiation under osmotic stress through arachidonic acid metabolism activation

Leandro Gastón Parra1,5, Cecilia Irene Casali1,5, Dylan Ezequiel Sendyk1,5, Ailén Florencia Salafia1, Sabrina Andrea Flor3,4,6, Silvia Edith Lucangioli2,4,6 and María del Carmen Fernández Tome1,5,*

Arachidonic acid (AA) metabolism plays a critical role in renal cell osmoadaptation. We recently demonstrated that hypertonicity induces the expression and activation of cytosolic phospholipase A2 (cPLA2). On one hand, AA released by cPLA2 enhances triacylglyceride (TG) synthesis and accumulation. On the other hand, AA is converted into prostaglandins (PG) through cyclooxygenase 2 (COX2) activity. Both processes are required for renal cell survival under osmotic stress. However, the mechanisms by which hypertonicity induces cPLA2 expression remain poorly understood. Given that we previously shown that hypertonicity regulates TG synthesis through the IRE1α-XBP1s branch of the unfolded protein (...)

Reversal of Cushing syndrome by antibody-mediated neutralization of ACBP/DBI

Zhe Shen1,2,3,a, Hui Pan1,2,4,a, Xiaolian Deng1,2,3, Oliver Kepp1,2, Isabelle Martins1,*, and Guido Kroemer1,2,5,*

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Quantifying replication stress in cancer without proliferation confounding

Philipp Jungk1 and Maik Kschischo1

The authors developed a refined gene expression signature (TRSS) that accurately measures replication stress independently of cell proliferation, addressing a major limitation of existing biomarkers that conflate stress with oncogene-driven growth. Applying this signature to patient samples, they discovered that replication stress is associated with activation of the non-homologous end-joining DNA repair pathway, suggesting cells may shift toward this repair mechanism under replication stress conditions.

Oxidative stress induces cortical stiffening and cytoskeletal remodelling in pre-apoptotic cancer cells

Aiman Jalmukhambetova1, Aidana Baltabekova1, Aizhan Tolebay1, Nargiz Rakhimgerey1, Ferdinand Molnár1, Tri Thanh Pham1, Agata N. Burska2,3 and Dos D. Sarbassov1,3

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Sugar accelerates chronological aging in yeast via ceramides

Vera Schmiedhofer1,a, Julian Sommersguter-Wagner1,a, Oskar Knittelfelder1,2, Helmut Jungwirth3, Gerald N. Rechberger1,4, Didac Carmona-Gutierrez1,4, Patrick Rockenfeller5, Christoph Ruckenstuhl1,4 and Frank Madeo1,4,6

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Bax- Bcl-xL interaction dynamics during the progression of cell cycle and cell death using FLIM-FRET

Aman Munirpasha Halikar1,2, Aneesh Chandrasekharan1, Asha Lekshmi1, Aswathy Sivasailam1, Jain Tiffee P J1,2, Shivanshu Kumar Tiwari1,2, Aijaz Ahmad Rather1,2 and TR Santhoshkumar1

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Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma

Tatiana P Grazioso1,2,3, Maria del Mar Rigual1, Cristian Perna4,5, Eduardo J Caleiras6 and Nabil Djouder1

INTRODUCTION Hepatocellular carcinoma (HCC) is the most common type of primary malignant tumor that arises from hepatocytes, the main functional cells of the liver 1. It is a leading cause

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