This month in Cell Stress: DNA helicases in genome stability. Image depicts structure of eukaryotic CMG helicase at a replication fork. PDB ID: 5U8S. Georgescu, R., Yuan, Z., Bai, L., de Luna Almeida Santos, R., Sun, J., Zhang, D., Yurieva, O., Li, H., O’Donnell, M.E. (2017) Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation. Proc. Natl. Acad. Sci. U.S.A. 114: E697-E706. Modified by Cell Stress.The cover is published under the CC BY 4.0 license.