Table of contents
Volume 5, Issue 8, pp. 119 - 127, August 2021
Cover: This month in
Cell Stress: Cytoskeleton-associated protein PDLIM1 in cancer. Image depicts actin cytoskeleton (orange) and nucleus (teal) staining. Public domain image by Alex Ritter, Jennifer Lippincott Schwartz and Gillian Griffiths, National Institutes of Health. The cover is published under the
CC BY 4.0 license.
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PDLIM1: Structure, function and implication in cancer
Jian-Kang Zhou, Xin Fan, Jian Cheng, Wenrong Liu and Yong Peng
Reviews |
page 119-127 | 10.15698/cst2021.08.254 | Full text | PDF |
Abstract
PDLIM1, a member of the PDZ-LIM family, is a cytoskeletal protein and functions as a platform to form distinct protein complexes, thus participating in multiple physiological processes such as cytoskeleton regulation and synapse formation. Emerging evidence demonstrates that PDLIM1 is dysregualted in a variety of tumors and plays essential roles in tumor initiation and progression. In this review, we summarize the structure and function of PDLIM1, as well as its important roles in human cancers.
