Figure 1: Treatment scheme for obese and ageing animals. (A) db/db mice were treated with D+Q for 2 months until 6 months of age. (B) Wild-type mice underwent several dietary restriction regimes. (C) Ink-ATTAC mice under high fat diet were treated with AP20187 for 4 months and (D) ageing Ink-ATTAC mice were treated for 3 months wit AP20187 or D+Q.