Back to article: Emerging roles of mitochondria and autophagy in liver injury during sepsis


Table 2. Release of intracellular contents from cells.

15. Struck J, Uhlein M, Morgenthaler NG, Furst W, Hoflich C, Bahrami S, Bergmann A, Volk HD, Redl H (2005). Release of the mitochondrial enzyme carbamoyl phosphate synthase under septic conditions. Shock 23(6): 533-538. http://www.ncbi.nlm.nih.gov/pubmed/?term=15897806

45. Crouser ED, Julian MW, Huff JE, Struck J, Cook CH (2006). Carbamoyl phosphate synthase-1: a marker of mitochondrial damage and depletion in the liver during sepsis. Crit Care Med 34(9): 2439-2446.https://doi.org/10.1097/01.CCM.0000230240.02216.21

46. Unuma K, Aki T, Matsuda S, Funakoshi T, Yoshida K, Uemura K (2013). Elimination and active extrusion of liver mitochondrial proteins during lipopolysaccharide administration in rat. Hepatol Res 43(5): 526-534.https://doi.org/10.1111/j.1872-034X.2012.01084.x

47. Unuma K, Aki T, Funakoshi T, Hashimoto K, Uemura K (2015). Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: Involvement of autophagy. Autophagy 11(9): 1520-1536.https://doi.org/10.1080/15548627.2015.1063765

58. Dupont N, Jiang S, Pilli M, Ornatowski W, Bhattacharya D, Deretic V (2011). Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1beta. EMBO J 30(23): 4701-4711.https://doi.org/10.1038/emboj.2011.398

59. Martins I, Wang Y, Michaud M, Ma Y, Sukkurwala AQ, Shen S, Kepp O, Metivier D, Galluzzi L, Perfettini JL, Zitvogel L, Kroemer G (2014). Molecular mechanisms of ATP secretion during immunogenic cell death. Cell Death Differ 21(1): 79-91.https://doi.org/10.1038/cdd.2013.75

60. Takenouchi T, Nakai M, Iwamaru Y, Sugama S, Tsukimoto M, Fujita M, Wei J, Sekigawa A, Sato M, Kojima S, Kitani H, Hashimoto M (2009). The activation of P2X7 receptor impairs lysosomal functions and stimulates the release of autophagolysosomes in microglial cells J Immunol 182(4): 2051-2062.https://doi.org/10.4049/jimmunol.0802577

61. Maeda A, Fadeel B (2014). Mitochondria released by cells undergoing TNF-alpha-induced necroptosis act as danger signals. 5: e1312.https://doi.org/10.1038/cddis.2014.277

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