Back to article: CRISPR-activation screen identified potassium channels for protection against mycotoxins through cell cycle progression and mitochondrial function
FIGURE 2: Overexpression and knockout of KCNJ4 and KCNJ12 regulates ZEA toxin resistance. (A) Knockout of KCNJ4 and KCNJ12 and the percentage cellular viability of cell lines after treatment with either 20 or 25 µM of ZEA. (B) Overexpression of KCNJ4 and KCNJ12 in another cell line (HIEC) and the percentage cellular viability after treatment with either 30 or 35 µM of ZEA. (C) Knockout of KCNJ4 and KCNJ12 in another cell line (HIEC) and the percentage cellular viability after treatment with either 30 or 35 µM of ZEA. Data are presented as the mean ± SEM (n=4). p < 0.05 (*), p < 0.01 (**) and p < 0.001 (***), calculated by Student t-test.