FIGURE 9: CcO is incorporated into mitochondrial SCs in patient biopsy samples. (A) CcO activity in human GBM tumors. Data are presented as the mean ± SEM (n=3). (B) Survival time of patients. (C) Representative Western blot showing the expression of COX4-1 in GBM tumors. Citrate synthase (CS) was probed as a loading control. (D) Densitometric analysis of Western blot in C. (E) Digitonin-solubilized mitochondria from GBM tumors were subjected to BN-PAGE followed by complex I and IV IGA assays and complex III Western blot analysis.