FIGURE 1: Postulated contribution of site-specific effects of RYGB on the gut barrier on glycemic control. (A) During diabetes remission after RYGB, the barrier-stabilising effects of jejunal and colonic content may outweigh the barrier-destabilising effects of ileal content leading to alleviation of endotoxemia-induced insulin resistance. (B) During diabetes relapse, the barrier-destabilising effects of ileal content may outweigh the barrier-stabilising effects of jejunal and colonic content leading to a return of endotoxemia-induced insulin resistance.