FIGURE 2: IL-33 nuclear function creates a switch-hitting cytokine in glioma progression. Schematics show the interplay between tumor associated macrophage (TAM) and glioma cells expressing full-length IL-33 (upper panel) or nuclear localization deficient IL-33 (ΔNLS-IL33; lower panel). Right panels show immunohistochemical images of brain sections from SCID mice bearing IL-33 (top) or ΔNLS-IL33 (bottom) expressing human glioma tumor cells co-stained for Iba-1 (green) to detect microglia/macrophage and anti-human nucleolin (red) to detect tumor cells.