TABLE 2. Natural products reported as ICD inducers.

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39. Krysko DV, Garg AD, Kaczmarek A, Krysko O, Agostinis P, Vandenabeele P (2012). Immunogenic cell death and DAMPs in cancer therapy. Nat Rev Cancer 12(12): 860-875. 10.1038/nrc3380

40. Turrini E, Catanzaro E, Muraro MG, Governa V, Trella E, Mele V, Calcabrini C, Morroni F, Sita G, Hrelia P, Tacchini M, Fimognari C (2018). Hemidesmus indicus induces immunogenic death in human colorectal cancer cells. Oncotarget 9(36): 24443-24456. 10.18632/oncotarget.25325

42. Uruena C, Gomez A, Sandoval T, Hernandez J, Li S, Barreto A, Fiorentino S (2015). Multifunctional T Lymphocytes Generated After Therapy With an Antitumor Gallotanin-Rich Normalized Fraction Are Related to Primary Tumor Size Reduction in a Breast Cancer Model. Integr Cancer Ther 14(5): 468-483. 10.1177/1534735415596425

43. Gomez-Cadena A, Uruena C, Prieto K, Martinez-Usatorre A, Donda A, Barreto A, Romero P, Fiorentino S (2016). Immune-system-dependent anti-tumor activity of a plant-derived polyphenol rich fraction in a melanoma mouse model. Cell Death Dis 7(6): e2243. 10.1038/cddis.2016.134

102. Sandoval TA, Uruena CP, Llano M, Gomez-Cadena A, Hernandez JF, Sequeda LG, Loaiza AE, Barreto A, Li S, Fiorentino S (2016). Standardized Extract from Caesalpinia spinosa is Cytotoxic Over Cancer Stem Cells and Enhance Anticancer Activity of Doxorubicin. Am J Chin Med 44(8): 1693-1717. 10.1142/S0192415X16500956

113. Yang Y, Li XJ, Chen Z, Zhu XX, Wang J, Zhang LB, Qiang L, Ma YJ, Li ZY, Guo QL, You QD (2012). Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner. PLoS One 7(12): e50811. 10.1371/journal.pone.0050811