FIGURE 1: A global overview of the protein dephosphorylation landscape in the DDR. The figure summarizes the participation of PP1, PP2A, PP4 and Cdc14 in each step of the DNA damage response. All phosphatase´s targets identified in different model organisms are also depicted (sc, Saccharomyces cerevisae; sp, Schizosaccharomyces pombe; ca, Candida albicans; d, Drosophila melanogaster; x, Xenopus; h, Human). The involvement of each protein phosphatase in the homologous recombination (A) and non-homologous end joining (B) pathways is portrayed. HR – homologous recombination, NHEJ – non-homologous end joining.