FIGURE 2: Myocardial metabolic adaptation to stress: failing heart (A) and diabetic heart (B). Abbreviations: TAG – triacylglycerol, CPT – carnitine palmitoyl transferase, G6P- glucose 6 phosphate, ETC – electron transport chain, CK – creatine kinase, CD36- fatty acid transporter, Glucosamine 6P – glucosamine 6-phosphate, PPP – pentose phosphate pathway, GLUT – glucose transporter, MCT – monocarboxylate transporter, PDH – pyruvate dehydrogenase, TCA – Kreb's cycle, βOX – beta oxidation, PCr – phosphocreatine, Cr – creatine, NFAT – Nuclear factor of activated T-cells, PPAR – Peroxisome proliferator-activated receptor, ROS – reactive oxygen species, polyol p-polyol pathway. Hypertrophy genes: Class II HDACs, GATA, NFAT, MEF