FIGURE 3: Reported cis-acting factors (red font) causing tumour suppressor promoter methylation and cancer risk [35][43][58][133]. TSS; transcription start site, ATG; translational start site, blue boxes; protein coding regions, pale blue boxes; 5′UTR. x

–

• Morak M, Koehler U, Schackert HK, Steinke V, Royer-Pokora B, Schulmann K, Kloor M, Hochter W, Weingart J, Keiling C, Massdorf T, Holinski-Feder E, German HC (2011). Biallelic MLH1 SNP cDNA expression or constitutional promoter methylation can hide genomic rearrangements causing Lynch syndrome. J Med Genet 48(8): 513-519. doi: 10.1136/jmedgenet-2011-100050
• Sloane MA, Nunez AC, Packham D, Kwok CT, Suthers G, Hesson LB, Ward RL (2015). Mosaic Epigenetic Inheritance as a Cause of Early-Onset Colorectal Cancer. JAMA Oncology 1(7): 953-957. doi: 10.1001/jamaoncol.2015.1484
• Esteller M, Garcia-Foncillas J, Andion E, Goodman SN, Hidalgo OF, Vanaclocha V, Baylin SB, Herman JG (2000). Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343(19): 1350-1354. doi: 10.1056/nejm200011093431901
• Gorodnova TV, Sokolenko AP, Ivantsov AO, Iyevleva AG, Suspitsin EN, Aleksakhina SN, Yanus GA, Togo AV, Maximov SY, Imyanitov EN (2015). High response rates to neoadjuvant platinum-based therapy in ovarian cancer patients carrying germ-line BRCA mutation. Cancer Lett 369(2): 363-367. doi: 10.1016/j.canlet.2015.08.028